[{"data":1,"prerenderedAt":46},["ShallowReactive",2],{"i-lucide:shield-check":3,"i-lucide:x":8,"i-lucide:arrow-right":10,"i-lucide:menu":12,"$fFu--ReOhdxvLkqthmM9CY0YrgdIdT5Flrcw_mv-LR6o":14,"i-lucide:arrow-left":30,"i-lucide:clock":32,"i-lucide:share-2":34,"i-lucide:bookmark":36,"i-lucide:printer":38,"i-lucide:check":40,"i-lucide:thumbs-up":42,"i-lucide:thumbs-down":44},{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":7},0,24,false,"\u003Cg fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\">\u003Cpath d=\"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z\"\u002F>\u003Cpath d=\"m9 12l2 2l4-4\"\u002F>\u003C\u002Fg>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":9},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M18 6L6 18M6 6l12 12\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":11},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M5 12h14m-7-7l7 7l-7 7\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":13},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M4 5h16M4 12h16M4 19h16\"\u002F>",{"slug":15,"title":16,"excerpt":17,"category":18,"author":19,"readingMinutes":22,"publishedAt":23,"cover":24,"tags":25,"gated":6,"body":29},"neuroplasticidad-depresion-resistente","Neuroplasticidad en depresión resistente al tratamiento: nuevas perspectivas terapéuticas","Revisamos la evidencia reciente sobre mecanismos de neuroplasticidad sináptica y su papel en la respuesta a antidepresivos de acción rápida.","Psiquiatría",{"name":20,"role":21},"Dra. María Fernanda Ruiz","Psiquiatra, INNN",9,"2026-04-02","https:\u002F\u002Fimages.unsplash.com\u002Fphoto-1559757175-5700dde675bc?q=80&w=1200&auto=format&fit=crop",[26,27,28],"depresión","neuroplasticidad","ketamina","La depresión resistente al tratamiento (DRT) afecta hasta al 30% de pacientes con trastorno depresivo mayor. La evidencia emergente sobre el papel de la neuroplasticidad sináptica, especialmente en relación con antagonistas del receptor NMDA, ha abierto nuevas líneas terapéuticas.\n\nEstudios recientes publicados en NEJM y Lancet Psychiatry demuestran que agentes como la esketamina intranasal inducen una rápida potenciación sináptica mediada por BDNF y mTOR, con efectos clínicos observables en horas en lugar de semanas.\n\nEn esta revisión analizamos: mecanismos moleculares, criterios diagnósticos actualizados para DRT, y protocolos de intervención en contexto mexicano.",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":31},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"m12 19l-7-7l7-7m7 7H5\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":33},"\u003Cg fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\">\u003Ccircle cx=\"12\" cy=\"12\" r=\"10\"\u002F>\u003Cpath d=\"M12 6v6l4 2\"\u002F>\u003C\u002Fg>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":35},"\u003Cg fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\">\u003Ccircle cx=\"18\" cy=\"5\" r=\"3\"\u002F>\u003Ccircle cx=\"6\" cy=\"12\" r=\"3\"\u002F>\u003Ccircle cx=\"18\" cy=\"19\" r=\"3\"\u002F>\u003Cpath d=\"m8.59 13.51l6.83 3.98m-.01-10.98l-6.82 3.98\"\u002F>\u003C\u002Fg>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":37},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M17 3a2 2 0 0 1 2 2v15a1 1 0 0 1-1.496.868l-4.512-2.578a2 2 0 0 0-1.984 0l-4.512 2.578A1 1 0 0 1 5 20V5a2 2 0 0 1 2-2z\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":39},"\u003Cg fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\">\u003Cpath d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\u002F>\u003Crect width=\"12\" height=\"8\" x=\"6\" y=\"14\" rx=\"1\"\u002F>\u003C\u002Fg>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":41},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M20 6L9 17l-5-5\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":43},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M15 5.88L14 10h5.83a2 2 0 0 1 1.92 2.56l-2.33 8A2 2 0 0 1 17.5 22H4a2 2 0 0 1-2-2v-8a2 2 0 0 1 2-2h2.76a2 2 0 0 0 1.79-1.11L12 2a3.13 3.13 0 0 1 3 3.88M7 10v12\"\u002F>",{"left":4,"top":4,"width":5,"height":5,"rotate":4,"vFlip":6,"hFlip":6,"body":45},"\u003Cpath fill=\"none\" stroke=\"currentColor\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M9 18.12L10 14H4.17a2 2 0 0 1-1.92-2.56l2.33-8A2 2 0 0 1 6.5 2H20a2 2 0 0 1 2 2v8a2 2 0 0 1-2 2h-2.76a2 2 0 0 0-1.79 1.11L12 22a3.13 3.13 0 0 1-3-3.88M17 14V2\"\u002F>",1776879281358]